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Daily weight-loss pill could be as effective as injectables

Apr 18, 2025, 7:06am EDT
An Eli Lilly manufacturing plant in Branchburg, New Jersey.
Mike Segar/File Photo/Reuters
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Eli Lilly’s share price soared after it said a daily weight-loss pill showed similar results to injectable drugs Ozempic and Mounjaro.

Orforglipron helped patients lose an average 7.9% of their body weight in 40 weeks in clinical trials, compared with the 1.6% weight lost by those taking a placebo.

The drug was less successful at reducing blood sugar, and at high doses about a quarter of patients experienced nausea, vomiting, or diarrhea.

GLP-1 drugs have transformed obesity treatments and have become some of the most popular medications in the world: About 12% of US adults have used them, and there have been regular shortages. A new version, especially in pill form, could widen access.

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